PO-0656: Dose intensified irradiation to brain metastases or resection cavity and low dose prophylactic cranial irradiation
نویسندگان
چکیده
منابع مشابه
Models support prophylactic cranial irradiation.
In this issue of the Journal of Clinical Oncology, Lee et al present a rather unique and useful statistical interpretation of the waxing question of prophylactic cranial irradiation (PCI) for patients with small-cell lung cancer (SCLC). The concept of PCI for SCLC has its origins in the comparison of the behavior of this disease with childhood leukemia, a disease that is essentially systemic in...
متن کاملRisk factors for brain metastases after prophylactic cranial irradiation in small cell lung cancer
Despite administration of prophylactic cranial irradiation (PCI), some small cell lung cancer (SCLC) patients still suffer from brain metastases (BM) with unknown risk factors. We conducted this study to identify patients with higher BM risk after PCI and improve their outcome. The characteristics and survival of all the SCLC patients underwent PCI in our institute from 2003 to 2014 were analyz...
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An unexpected hypersensitivity has been reported for several cell lines at low doses (<1Gy), which is not consistent with the linear-quadratic approach currently used in general for the description of survival curves [1,2,3,4]. The corresponding substructure of the survival curves has been attributed to induced radioresistance. There are indications, that high-LET irradiation with neutron or pi...
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With the increase in the amount of time spent EVA that is necessary to complete the construction and subsequent maintenance of ISS, it will become increasingly important for ground support personnel to accurately characterize the radiation exposures incurred by EVA crewmembers. Since exposure measurements cannot be taken within the organs of interest, it is necessary to estimate these exposures...
متن کاملEffects of single-dose and fractionated cranial irradiation on rat brain accumulation of methotrexate.
The effects of single-dose and fractionated whole-brain irradiation on brain methotrexate (MTX) has been studied in a rat model. The amount of MTX present in the brain 24 hr after a single i.p. dose (100 mg/kg) was the same wether animals were sham irradiated or given a single dose of 2000 rads 6 or 48 hr prior to the drug (6.9, 8.3, and 6.8 pmol MTX/g, wet weight, respectively). Animals sham i...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2013
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(15)32962-5